Long-term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor
نویسندگان
چکیده
BACKGROUND Symptoms of spasmodic dysphonia (SD) are usually managed successfully with botulinum toxin injections. Vocal tremor (VT), which accompanies SD, has a poor response to this treatment. CASE REPORT We report a case of a female with SD and VT who became symptom-free for 10 months after the intake of a single dose of sodium oxybate (Xyrem®). The long-term treatment effect correlated with attenuated brain activity in the key regions of dystonic brain network. DISCUSSION Our case demonstrates that the novel treatment of sodium oxybate may hold promise for SD patients, especially those who have associated VT.
منابع مشابه
Case Reports Long-term Effect of Sodium Oxybate (XyremH) in Spasmodic Dysphonia with Vocal Tremor
Background: Symptoms of spasmodic dysphonia (SD) are usually managed successfully with botulinum toxin injections. Vocal tremor (VT), which accompanies SD, has a poor response to this treatment. Case Report: We report a case of a female with SD and VT who became symptom-free for 10 months after the intake of a single dose of sodium oxybate (XyremH). The long-term treatment effect correlated wit...
متن کاملAn open-label study of sodium oxybate in Spasmodic dysphonia.
OBJECTIVES/HYPOTHESIS Spasmodic dysphonia (SD) is a task-specific laryngeal dystonia that affects speech production. Co-occurring voice tremor (VT) often complicates the diagnosis and clinical management of SD. Treatment of SD and VT is largely limited to botulinum toxin injections into laryngeal musculature; other pharmacological options are not sufficiently developed. STUDY DESIGN Open-labe...
متن کاملIsolated vocal tremor as a focal phenotype of essential tremor: a retrospective case review
BACKGROUND Essential tremor (ET) is a common condition associated with significant physical and psychosocial disability. "Classic" ET is a clinical syndrome of action tremor in the upper limbs and less commonly the head, jaw, voice, trunk, or lower limbs. Current diagnostic criteria for ET exclude isolated vocal tremor (IVT). Failure to recognize IVT as a form of ET may contribute to misdiagnos...
متن کاملSpasmodic Dysphonia and Thalamic Deep Brain Stimulation: Long-term Observations, Possible Neurophysiologic Mechanism and Comparison of Unilateral Versus Bilateral Stimulation
The association of upper extremity essential tremor and several types of other dystonias, including spasmodic dysphonia, have been reported in the past [1,2]. We previously reported a brief case description of a patient with essential tremor (ET) of the hands and adductor spasmodic dysphonia (SD) with vocal tremor who responded to bilateral thalamic DBS with six month follow up [3]. Our patient...
متن کاملTremor in speakers with spasmodic dysphonia
the objective of this work is the estimation of vocal tremor in patients with spasmodic dysphonia before and after treatment, and the comparison of their tremor characteristics with those estimated from healthy speakers. as an outcome, a new tremor attribute is introduced, the deviation of the modulation level and a novel method is proposed for classifying speakers according to the prevalence o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2013